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Inactivation of Norovirus by ozone gas in conditions relevant to
healthcare
J.B. Hudson a, b, , M. Sharma a and M.
Petricb, c
a Viroforce Systems Inc. Laboratory, Vancouver, Canada
b Department of Pathology & Laboratory Medicine, University of
British Columbia, Canada
c British Columbia Centre for Disease Control, Vancouver, Canada
12 March 2007.
Summary
We evaluated the ability of ozone gas to inactivate Norovirus and
its animal surrogate feline calicivirus (FCV) in dried samples
placed at various locations within a hotel room, a cruise liner
cabin and an office. Norovirus was measured by quantitative reverse
transcriptase real-time polymerase chain reaction (QRT-PCR) assay,
and FCV by a combination of QRT-PCR and virus infectivity assays. We
were able to reduce the concentration of infectious FCV by a factor
of more than 103, and in some cases beyond detection, under optimal
conditions of ozone exposure with less than an hour of total
operation. QRT-PCR assays indicated similar decreases in both viral
RNAs. Virus-containing samples dried onto hard surfaces (plastic,
steel and glass), and soft surfaces such as fabric, cotton and
carpet, were equally vulnerable to the treatment. Our results show
that Norovirus can be inactivated by exposure to ozone gas from a
portable commercial generator in settings such as hotel rooms,
cruise ship cabins and healthcare facilities.
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